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Publications

Alterations of atrial Ca2+ handling as cause and consequence of atrial fibrillation.

Cardiovasc Res. 2011; 89:722-733.


Ultra-rapid delayed rectifier channels: molecular basis and therapeutic implications.

Cardiovasc Res. 2011; 89:776-785.


Inhibition of CaMKII Phosphorylation of RyR2 Prevents Induction of Atrial Fibrillation in FKBP12.6 Knockout Mice.

Circ Res. 2012; 110:465-470.


Defects in ankyrin-based membrane protein targeting pathways underlie atrial fibrillation.

Circulation 2011; 124(11):1212-1222.


Recent advances in the molecular pathophysiology of atrial fibrillation.

J Clin Invest. 2011; 121(8):2955-2968.


Oxidized CaMKII causes cardiac sinus node dysfunction in mice.

J Clin Invest. 2011; 121(8):3277-3288.


Left Atrial Catheter Ablation and Ischemic Stroke.

Stroke 2012; 43:265-270.


Myocardial Redox State Predicts In-Hospital Clinical Outcome After Cardiac Surgery: Effects of Short-term Preoperative Statin Treatment.

J Am Coll Cardiol. 2012; 59(1):60-70.


Atrial sources of reactive oxygen species vary with the duration and substrate of atrial fibrillation: implications for the antiarrhythmic effect of statins.

Circulation 2011; 124(10):1107-1117.


Pathophysiological mechanisms of atrial fibrillation: a translational appraisal.

Physiol Rev. 2011; 91(1):265-325.


Overexpression of cAMP-response element modulator causes abnormal growth and development of the atrial myocardium resulting in a substrate for sustained atrial fibrillation in mice.

Int J Cardiol. 2013; 166(2): 366-374.


Systematic Analysis of Gene Expression Differences between Left and Right Atria in Different Mouse Strains and in Human Atrial Tissue.

PLoS ONE 2011; 6(10):e26389.


PITX2c is expressed in the adult left atrium, and reducing Pitx2c expression promotes atrial fibrillation inducibility and complex changes in gene expression.

Circ Cardiovasc Genet. 2011; 4:123-133.


EUTRAF, the European network for Translational Research in Atrial Fibrillation.

Clin Investig (Lond) 2012; 2:1061-1067.


The multidimensional role of calcium in atrial fibrillation pathophysiology: mechanistic insights and therapeutic opportunities.

Eur Heart J. 2012; 33(15):1870-1877.


Novel molecular targets for atrial fibrillation therapy.

Nat Rev Drug Discov. 2012; 11(4):275-291.


Enhanced sarcoplasmic reticulum Ca2+ leak and increased Na+-Ca2+ exchanger function underlie delayed afterdepolarizations in patients with chronic atrial fibrillation.

Circulation 2012; 125(17):2059-2070.


Proarrhythmic atrial calcium cycling in the diseased heart.

Adv Exp Med Biol. 2012; 740:1175-1191.


Calcium handling and atrial fibrillation.

Wien Med Wochenschr. 2012; 162(13-14):287-291.


Is altered atrial microRNA-ome a critical contributor to the pathophysiology of atrial fibrillation?

Basic Res Cardiol. 2012; 107:284.


An Introduction to Murine Models of Atrial Fibrillation.

Front Physiol. 2012; 3:296.


Systems approaches to post-operative atrial fibrillation – do they help us to better understand the ionic basis of the arrhythmogenic substrate?

J Mol Cell Cardiol. 2012; 53:320-322.


Voltage-gated Na+ channels: novel players in fibroblast-to-myofibroblast transition with a potential role in atrial arrhythmogenesis?

J Physiol. 2012; 590 (20):4975.


Cellular and Molecular Correlates of Ectopic Activity in Patients with Atrial Fibrillation.

Europace 2012; 14 (Suppl. 5): v97-v105.


Automated Quantification of Atrial Fibrillation Complexity by Probabilistic Electrogram Analysis and Fibrillation Wave Reconstruction.

Conf Proc IEEE Eng Med Biol Soc. 2012; 2012: 6357-6360.


Stability of complex fractionated atrial electrograms: a systematic review.

J Cardiovasc Electrophysiol. 2012; 23(9):980-987.


A computer model of endo-epicardial electrical dissociation and transmural conduction during atrial fibrillation.

Europace. 2012; 14 (Suppl. 5):v10-v16.


Neutral effects of statins to prevent atrial fibrillation recurrences after catheter ablation of atrial fibrillation: should we bury upstream therapy for secondary prevention?

Heart Rhythm 2012; 9(2):179-180.


Minimally invasive closed-chest ultrasound-guided substance delivery into the pericardial space in mice.

Naunyn Schmiedeberg´s Arch Pharmacol. 2013; 386:227-238.


New directions in antiarrhythmic drug therapy for atrial fibrillation.

Future Cardiol. 2013; 9(1):71-88.


Atrial arrhythmogenesis in catecholaminergic polymorphic ventricular tachycardia – is there a mechanistic link between sarcoplasmic reticulum Ca2+ leak and re-entry?

Acta Physiol (Oxf.). 2013; 207(2):208-211.


Electrical Storm: Recent Pathophysiological Insights and Therapeutic Consequences.

Basic Res Cardiol. 2013; 108(2):336-345.


The biology of human pulmonary veins: does it help us to better understand AF pathophysiology in patients?

Heart Rhythm 2013; 10(3):392-393.


Gone fishing (for silent atrial fibrillation).

Circulation 2013; 127:870-872.


Human epicardial adipose tissue induces fibrosis of the atrial myocardium through the secretion of adipo-fibrokines.

European Heart Journal 2013; Mar 22 published ahead of print.


Characterization of two genetic variants of Nav1.5-Arginine 689 found in patients with cardiac arrhythmias.

J Cardiovasc Electrophys. 2013; 24:1037-1046.


Human Electrophysiological and Pharmacological Properties of XEN-D0101: A Novel Atrial-Selective Kv1.5/IKur Inhibitor.

J Cardiovasc Pharmacol. 2013; 61:408-415.


Targeting inflammation and oxidative stress in atrial fibrillation: Role of HMG-CoA reductase inhibition with statins.

Antioxid Redox Signal. 2013; Oct 19 published ahead of print.


Selective atrial profibrotic signalling in mice and man.

Cardiovasc. Res. 2013; 99:592-594.


Personalised management of atrial fibrillation:

Proceedings from the 4th AFNET/EHRA consensus conference. Europace 2013; 15:1540-1556.


Atrial selectivity of antiarrhythmic drugs.

J Physiol. 2013; 1-11.


Isolation of human atrial myocytes for simultaneous measurements of Ca2+ transients and membrane currents.

J Vis Exp. 2013; e50235.


Safety and efficacy of vernakalant for acute cardioversion of atrial fibrillation: an update.

Vasc Health Risk Manag. 2013; 9:165-175.


Pleiotropic actions of amiodarone: still puzzling after half a century.

Naunyn Schmiedeberg’s Arch Pharmacol. 2013; 386(7):571-574.


KCNQ1 autoantibodies: another way to regulate IKs.

Cardiovasc Res. 2013; 98(3):329-331.


Impaired Na+-dependent Regulation of Acetylcholine-activated Inward-Rectifier K+ Current Modulates Action Potential Rate Dependence in Patients with Chronic Atrial Fibrillation.

J Mol Cell Cardiol. 2013; 61:142-152.


Loss of continuity in the thin epicardial layer due to endomysial fibrosis increases the complexity of atrial fibrillatory conduction.

Circ Arrhythm Electrophysiol. 2013; 6(1): 202-211.


Transmural conduction is the predominant mechanism of breakthrough during atrial fibrillation: evidence from simultaneous endo-epicardial high-density activation mapping.

Circ Arrhythm Electrophysiol. 2013; 6(2):334-341.


The new antiarrhythmic drug vernakalant: ex vivo study of human atrial tissue from sinus rhythm and chronic atrial fibrillation.

Cardiovasc Res. 2013; 98(1):145-154.


Dynamic remodelling of intracellular Ca2+ signalling during atrial fibrillation.

J Mol Cell Cardiol. 2013; 58:134-142.


Inverse Relationship between Fractionated Electrograms and Atrial Fibrosis in Persistent Atrial Fibrillation – A combined MRI and High Density Mapping.

J Am Coll Cardiol. 2013; 62(9):802-812.


Validation of novel 3D electrocardiographic mapping of atrial tachycardias by invasive mapping and ablation: A multicenter study.

J Am Coll Cardiol. 2013; 62(10): 889-897.


Rhythm control of atrial fibrillation in heart failure.

Heart Fail Clin. 2013; 9(4):407-415.


Mutation E169K in junctophilin-2 causes atrial fibrillation due to impaired RyR2 stabilization.

J Am Coll Cardiol. 2013; 62(21):2010-2019.


Pleiotropic effects of antiarrhythmic agents: dronedarone in the treatment of atrial fibrillation.

Clin Med Insights: Cardiol. 2013; 7:127-140.


Function and regulation of Serine/Threonine phosphatases in the healthy and diseased heart.

J Mol Cell Cardiol. 2013; 64c:90-98.


Oxidized CaMKII Triggers Atrial Fibrillation.

Circulation 2013; 128:1748-1757.


Rearrangement of Atrial Bundle Architecture and consequent changes in Anisotropy of Conduction constitute the 3-dimensional Substrate for Atrial Fibrillation.

Circ Arrhythm Electrophysiol. 2013; 6:967-975.


Coagulation factor X induces an inflammatory signaling by activation of protease-activated receptors in human atrial tissue.

European Journal of Pharmacology 2013; 718(1-3):114-23.


Identification of recurring wavefront propagation patterns in atrial fibrillation using basis pursuit.

Conf Proc IEEE Eng Med Biol Soc. 2013; 2013:2928-2931.


Shear stress triggers insertion of voltage-gated potassium channels from intracellular compartments in atrial myocytes.

Proc Natl Acad Sci USA. 2013; 110(41):E3955-3964.


Low stroke risk after elective cardioversion of atrial fibrillation: An analysis of the Flec-SL trial.

Int J Cardiol. 2013; 168(4):3977-3981.


Upstream Therapy for Atrial Fibrillation in Heart Failure.

Heart Fail Clin. 2013; 9(4):417-425.


Macromolecular Complexes and Cardiac Potassium channels.

In: Cardiac Electrophysiology: From Cell to Bedside. Zipes D, Jalife J (eds), 6th edition, Saunders/Elsevier, 2014; 197-204.


Cholinergic and constitutive regulation of atrial potassium channels.

In: Cardiac Electrophysiology: From Cell to Bedside. Zipes D, Jalife J (eds), 6th edition, Saunders/Elsevier, 2014; 381-391.


The molecular pathophysiology of atrial fibrillation.

In: Cardiac Electrophysiology: From Cell to Bedside. Zipes D, Jalife J (eds), 6th edition, Saunders/Elsevier, 2014; 449-458.


New Antiarrhythmic Drugs and New Concepts for Old drugs.

In: Cardiac Electrophysiology: From Cell to Bedside. Zipes D, Jalife J (eds), 6th edition, Saunders/Elsevier 2014; 1111-1119.


A Bilayer Representation of the Human Atria.

Conf Proc IEEE Eng Med Biol Soc. 2013; 2013:1530-1533.


A Computational Bilayer Surface Model.

In: Functional Imaging and Modeling of the Heart. Ourselin S, Rueckert D, Smith N (eds), FIMH 2013, LNCS7945, 27-34, 2013.


Feasibility of MR-guided catheter radiofrequency ablation in the sheep heart.

Cellular and Molecular Mechanisms of Atrial Arrhythmogenesis in Patients with Paroxysmal Atrial Fibrillation.

Circulation. 2014, 129(2): 145-156.


Cardiac Safety Assays.

Curr Opin Pharmacol. 2014, 15: 16-21.


Epicardial adipose tissue and atrial fibrillation.

Cardiovasc Res


Calcium dysregulation in atrial fibrillation: the role of CaMKII.

Front Pharmacol


Atrial supply-demand balance in healthy adult pigs: coronary blood flow, oxygen extraction, and lactate production during acute atrial fibrillation.

Cardiovasc Res


Clinical correlates of echocardiographic tissue velocity imaging abnormalities of the left atrial wall during atrial fibrillation.

Europace


Effects of IKur blocker MK-0448 on human right atrial action potentials from patients in sinus rhythm and in permanent atrial fibrillation. Front Pharmacol
Upstream therapy for atrial fibrillation.

Herzschr Elektrophys


MicroRNA Regulation and Cardiac Calcium Signaling: Role in Cardiac Disease and Therapeutic Potential.

Circ Res


Role of RyR2 Phosphorylation in Heart Failure and Arrhythmias: Controversies around Ryanodine Receptor Phosphorylation in Cardiac Disease.

Circ Res


Atrial calpains: mediators of atrial myopathies in atrial fibrillation.

JAFIB


The Clinical Profile and Pathophysiology of Atrial Fibrillation: Relationships among Clinical Features, Epidemiology, and Mechanisms.

Circ Res


Cellular and Molecular Electrophysiology of Atrial Fibrillation Initiation, Maintenance and Progression.

Circ Res


Constitutive Activity of the Acetylcholine-Activated Potassium Current IK,ACh in Cardiomyocytes.

Advances in Pharmacology


Impaired Local Regulation of Ryanodine Receptor Type-2 by Protein Phosphatase 1 Promotes Atrial Fibrillation.

Cardiovasc Res


Small conductance calcium-activated potassium (SK) channels contribute to action potential repolarization in human atria.

Cardiovasc Res


Cardiac mechano-electric coupling research: Fifty years of progress and scientific innovation.

Prog Biophys Mol Biol


Tachycardia-induced silencing of subcellular Ca2+ signaling in atrial myocytes.

J Clin Invest


Reconstruction of instantaneous phase of unipolar atrial contact electrogram using a concept of signal sinusoidal recomposition and Hilbert transform.

Conf Proc IEEE Transactions on Biomedical Engineering


Aggravation of Myofibroblast Arrhythmogeneicity by Mechanical Stress.

Cardiovasc Res


Cardiac arrythmias: multimodal assessment integrating body surface ECG mapping into cardiac imaging.

Radiology


Atrial structure and function 5 years after successful ablation for persistent atrial fibrillation: an MRI study.

J Cardiovasc Electrophysiol


Driver domains in persistent atrial fibrillation.

Circulation


Pulmonary vein isolation using a circular, open irrigated mapping and ablation catheter (nMARQ): a report on feasibility and efficacy.

Europace


Rat engineered heart tissue: a novel tool in the safety pharmacology toolkit?

Basic Res Cardiol


A bilayer model of human atria: mathematical background, construction, and assessment.

Europace


Application of phase coherence in assessment of spatial alignment of electrodes during simultaneous endocardial-epicardial direct contact mapping of atrial fibrillation.

Europace


Inter-Subject Variability in Human Atrial Action Potential in Sinus Rhythm versus Chronic Atrial Fibrillation.

Sachez C et al. PLoS One 2014


Alterations in the Interactome of Serine/Threonine Protein Phosphatase Type-1 in Atrial Fibrillation patients.

Chiang et al. JACC VOL.65, NO.2, 2015. JANUARY 20, 2015: 163 – 73


Application of the RIMARC algorithm to a large data set of action potentials and clinical parameters for risk prediction of atrial fibrillation.

Ravens et al. Med Biol Eng Comput 2014


Loss of MicroRNA-106b-25 Cluster Promotes Atrial Fibrillation by Enhancing Ryanodine Receptor Type-2 Expression and Calcium Release.

Chiang et al. Circ Arrhythm Electrophysiol. 2014;7:1214-1222


Five-Year Outcome of Catheter Ablation of Persistent Atrial Fibrillation Using Termination of Atrial Fibrillation as a Procedural Endpoint.

Scherr et al. 2015


Early subcellular Ca2+ remodeling and increased propensity for Ca2+ alternans in left atrial myocytes from hypertensive rats.

Pluteanu et al. 2015


Age, Atrial Fibrillation and Structural Heart Disease are the Main Determinants of Left Atrial Fibrosis Detected by Delayed-Enhanced Magnetic Resonance Imaging in a General Cardiology Population.

Cochet et al. 2015


Atrial-like cardiomyocytes from human pluripotent stem cells are a robust preclinical model for assessing atrial-selective pharmacology.

Devalla et al. 2015


Novel K+ channel targets in atrial fibrillation drug development – where are we?

Ford et al. 2015


Atrial fibrillation and rapid acute pacing regulate adipocyte / adipositas-related gene expression in the atria.

Chilukoti et al. 2015


Atrial fibrillation and obesity: not just a coincidence.

Hatem SN. 2015


Identification of microRNA-mRNA dysregulations in paroxysmal atrial fibrillation.

Chiang et al. 2015


Altered atrial metabolism: an underappreciated contributor to the initiation and progression of atrial fibrillation.

Ghezelbash et al. 2015


Calcium handling abnormalities as a target for atrial fibrillation therapeutics: How close to clinical implementation?

Heijman et al. 2015


Quantification of the transmural dynamics of atrial fibrillation by simultaneous endocardial and epicardial optical mapping in an acute sheep model.

Gutbrod et al. 2015


Focal Arrhythmia Ablation Determined by High Resolution Non-invasive Maps: Multicenter Feasibility Study.

Hocini et al. 2015


Pathophysiology and progression of atrial fibrillation: Do we have a comprehensive model?

Ravens U. 2015


Human epicardial adipose tissue has a specific transcriptomic signature depending on its anatomical peri-atrial, peri-ventricular, or peri-coronary location.

Gaborit B, Venteclef, N, Hatem SN, Clement, K


Is epicardial adipose tissue an epiphenomenon or a new player in the pathophysiology of atrial fibrillation?

Hatem SN.


A glimpse at cardiac ion channel macromolecular complexes.

Balse E, Hatem SN


Dynamic of Ion Channel Expression at the Plasma Membrane of Cardiomyocytes.

Balse E, Hatem SN


Late Sodium Current in Human Atrial Cardiomyocytes from Patients in Sinus Rhythm and Atrial Fibrillation

Poulet C, Fabritz, L, Ravens U


The European Network for Translational Research in Atrial Fibrillation (EUTRAF): objectives and initial results.

Schotten U, Hatem S, et al.


The positive frequency-dependent electrophysiological effects of the IKur inhibitor XEN-D0103 are desirable for the treatment of atrial fibrillation.

Ford J, Milnes J, Ravens U


Atrial Fibrillation Activates AMP-Dependent Protein Kinase and its Regulation of Cellular Calcium Handling: Potential Role in Metabolic Adaptation and Prevention of Progression.

Harada M, Voigt N, Dobrev D, Nattel S


Upregulation of K2P3.1 K+ current causes action potential shortening in patients with chronic atrial fibrillation.

Schmidt C, Voigt N, Heijman J, Dobrev D, Thomas D


Tools to keep the clock ticking: molecular approaches to treat sinus node dysfunction.

Heijman J, Heusch G, Dobrev D


Irregular rhythm and atrial metabolism are key for the evolution of proarrhythmic atrial remodeling in atrial fibrillation.

Heijman J, Dobrev D


Expression and function of Kv1.1 potassium channels in human atria from patients with atrial fibrillation.

Glasscock E, Voigt N, Dobrev D, Wehrens XHT


Methods for isolating atrial cells from large mammals and humans.

Voigt N, Pearman CM, Dobrev D, Dibb K.


New antiarrhythmic targets in atrial fibrillation.

Voigt N, Heijman J, Dobrev D


Pathophysiologie des Vorhofflimmerns: Neue zelluläre und molekulare Erkenntnisse.

Ghezelbash S, Dobrev D


Innovative therapeutics for atrial fibrillation: Imminent breakthroughs or much ado about nothing?

Nattel S, Dobrev D


An update on atrial fibrillation in 2014: from pathophysiology to treatment.

Ferrari R, Dobrev D, Kirchhof P, Ravens U, Vicedomini GG


Computational models of atrial cellular electrophysiology and calcium handling, and their role in atrial fibrillation.

Heijman J, Abdoust PE, Voigt N, Nattel S, Dobrev D


Redox control of cardiac remodelling in atrial fibrillation.

Wolke C, Bukowska A, Goette A, Lendeckel U


A porcine model of hypertensive cardiomyopathy: implications for heart failure with preserved ejection fraction.

Schwarzl M, Manninger M, Reilly S, Zweiker D, Pieske B, Casadei B, Post H


Atrial Fibrillation is associated with the fibrotic remodelling of adipose tissue in the subepicardium of adipose tissue of human and sheep atria.

Haemers P, Lendeckel U, Jaïs P, Hatem SN


nMARQ Ablation for Atrial Fibrillation: Results from a Multicenter Study.

Mahida S, Haissaguerre M, Jais P


Indices of bipolar complex fractionated atrial electrograms correlate poorly with each other and atrial fibrillation substrate complexity.

Lau DH, Maesen B, Zeemering S, Schotten U

Comprehensive risk reduction in patients with atrial fibrillation: Emerging diagnostic and therapeutic options.

A report from the 3rd AFNET/EHRA consensus conference. Thromb Haemostat 2011, 1012-1019. Europace 2012, 8-27


Short-term versus long-term antiarrhythmic drug treatment after cardioversion of atrial fibrillation (Flec-SL): a prospective, randomised, open-label, blinded endpoint assessment trial.

The Lancet 2012, 238-46


A proposal for new clinical concepts in the management of atrial fibrillation.

Am Heart J 2012, 292-302


Expert consensus statement on catheter and surgical ablation of atrial fibrillation: recommendations for patient selection, procedural techniques, patient management and follow-up, definitions, endpoints, and research trial design: a report of the Heart Rhythm Society (HRS) Task Force on Catheter and Surgical Ablation of Atrial Fibrillation.

Heart Rhythm 2012, 632-96. Europace 2012, 528-606


Venice Chart International Consensus Document on Atrial Fibrillation Ablation.

J Cardiovasc Electrophysiol 2012, 890-923


The management of patients with atrial fibrillation undergoing percutaneous coronary intervention with stent implantation: In-hospital-data from the Atrial Fibrillation undergoing Coronary Artery Stenting (AFCAS) study.

Catheter Cardiovasc Interv. In press 2013


Atrial fibrillation: current recommendations for diagnosis and treatment.

Internist (Berl) 2013, 583-95


European Heart Rhythm Association Practical Guide on the use of new oral anticoagulants in patients with non-valvular atrial fibrillation.

Europace 2013, 625-51


EHRA Practical Guide on the use of new oral anticoagulants in patients with non-valvular atrial fibrillation: executive summary.

Eur Heart J Published online 26th April 2013


Atrial supply–demand balance in healthy adult pigs: coronary blood flow, oxygen extraction, and lactate production during acute atrial fibrillation.

Cardiovascular Research (2014) 101, 9–19


Clinical correlates of echocardiographic tissue velocity imaging abnormalities of the left atrial wall during atrial fibrillation.

Europace Advance Access, March 25, 2014


Effects of IKur blocker MK448 on human right atrial action potentials from patients insinus rhythm and inpermanent atrial fibrillation.

www.frontiersin.org March2014 | Volume5 | Article26


Upstream-Therapie bei Vorhofflimmern.

Herzschr Elektrophys 2014 ∙ 25:33–40


MicroRNA Regulation and Cardiac Calcium Signaling: Role in Cardiac Disease and Therapeutic Potential.

Circ Res. 2014; 114:689-705


Epicardial adipose tissue and atrial fibrillation.

Cardiovascular Research Advance Access published March 19, 2014


Calcium dysregulation inatrial fibrillation: the role of CaMKII.

www.frontiersin.org March2014 | Volume5 | Article30


Role of RyR2 Phosphorylation in Heart Failure and Arrhythmias: Controversies Around Ryanodine Receptor Phosphorylation in Cardiac Disease.

Circ Res. 2014; 114:1311-1319


Cardiac mechano-electric coupling research: Fifty years of progress and scientific innovation

www.elsevier.com/locate/pbiomolbio
Progress in Biophysics and Molecular Biology (2014) 1e4


Small-conductance calcium-activated potassium (SK) channels contribute to action potential repolarization in human atria

Cardiovascular Research (2014) 103, 156–167


The Clinical Profile and Pathophysiology of Atrial Fibrillation: Relationships Among Clinical Features, Epidemiology, and Mechanisms

Circ Res. 2014;114:1453-1468


Cellular and Molecular Electrophysiology of Atrial Fibrillation Initiation, Maintenance, and Progression

Circ Res. 2014;114:1483-1499


Voigt (2014) – Constitutive activity of the acetylcholine-activated potassium current IKACh in cardiomyocytes

Advances in Pharmacology, Vol. 70, Burlington: Academic Press, 2014, pp. 393-409.


Impaired local regulation of ryanodine receptor type 2 by protein phosphatase 1 promotes atrial fibrillation

Cardiovascular Research (2014) 103, 178–187.